Avicenna Days 2023

Diversity & Inclusion in the In Silico Approaches

Programme

October 10th – Focus on Regulatory – «Uncovering the regulatory pathway»

14:00 - 14:05 Welcome
Roberta Maggi, Office Manager, Avicenna Alliance

14:05 - 14:20 Introduction to Avicenna Alliance
Thierry Marchal, Secretary General, Avicenna Alliance, Ansys

14:20 - 14:35 Introduction to the topic
Cécile Rousseau, In Silico Application WG, Master of Ceremony, Avicenna Alliance, VCLS

14:35 - 14:50 "Adoption of Modelling and Simulation-based methods for High Impact applications: An European regulator’s perspective", Keynote Speaker, Flora Musuamba, Vice Chair Person, EMA

14:50 - 15:05 “Uncovering the MIDD Paired Meeting Pathway”, Keynote Speaker, Raj Madabushi, Associate Director, FDA 15:05 - 15:20 “In silico confidence: the regulatory journey for computational modeling and medical devices“, Keynote Speaker, Pras Pathmanathan, Senior Scientist, FDA

15:20 - 15:35 BREAK

15:35 - 15:50 "Charting the Future: Unveiling the Regulatory Complexities of In Silico Trials with the Regulatory Agencies”, Francesco Pappalardo, Full Professor, University of Catania, Mimesis

15:50 - 16:05 “A path towards a comprehensive regulatory framework for acceptance of in silico evidence (Countries experiences)”, Martha De Cunha, Policy Development WG, Avicenna Alliance, Edwards Lifesciences

16:05 - 16:20 "Going Towards Good Simulation Practices", Luca Emili, GSP Task Force, InSilicoTrials

16:20 - 16:30 "Artificial intelligence-driven drug development against autoimmune diseases", Case study, Philippe Moingeon, Head of Therapeutic Area, Servier

16:30 - 16:40 ‘Scoping and Validating an In Silico Clinical Trial: A Case Study on a Shoulder Stem",’Case study, Jeff Bischoff, Senior Research Director, Zimmer Biomet

16:40 - 16:50 “In Silico Advancements in Cardiovascular Device Design and Approval”, Case study, Simon Sonntag, Notified Bodies TF, Virtonomy

16:50 - 17:00 "In-silico trial of intracranial flow diverters replicates and expands insights from conventional clinical trials", Case study, Alejandro Frangi, UK In Silico Regulatory Innovation TF, University of Manchester

17:00 - 17:15 BREAK

17:15 - 18:00 Panel discussion / Round Table.
Moderator: Emmanuelle Voisin, Founder & CEO, VCLS
Speakers: Ulrike Schroeder, Senior Project Manager, DIN
Puja Myles, Director CPRD, MHRA
Payman Afshari, Senior Principal Engineer, J&J
Mark Palmer, Senior Chief Technologist for Healthcare, Ansys.

18:00 - 18:15 Wrap up
Thierry Marchal, Secretary General, Avicenna Alliance, Ansys

October 11th – Focus on Research – «Building reliable models»

14:00 - 14:20 Introduction to tasks forces & community-based initiatives
Liesbet Geris, Research & Technology WG, Master of Ceremony, Avicenna Alliance, VPHi

14:20 - 14:50 “Why do we need Medical Digital Twins?”, Frank Rademakers, Keynote Speaker, Emeritus Professor Cardiology, KU Leuven

14:50 - 15:20 "Building digital twins for complex human diseases", Anna Niarakis, Professor, University of Toulouse III - Paul Sabatier, Center of Integrative Biology, Immune Digital Twin Consortium

15:20 - 15:35 "Supercomputer-based cardiac virtual human twins”, Mariano Vazquez, Co-founder, President, and CTO, ELEM Biotech

15:35 - 15:50 "Conception and evaluation of a biomechanical model of the lowerlimb", Antoine Perrier, Strategic and medical chief officer, Twinsight

15:50 - 16:10 BREAK

16:10 - 16:40 "Modeling and Simulation for Treatment Planning in Cardiovascular Disease in SimVascular", Keynote Speaker, Alison Marsden, Professor, Stanford University

16:40 - 16:55 "Responses of Hypertensive Virtual Population to Calcium Channel Blocker Treatment: Comparison to a Real Population", Robert Hester, Professor Emeritus, UMMC (University of Mississippi Medical Center).

16:55 - 17:00 Introduction to the round table – Marc Horner, Global Harmonization TF, Ansys

17:00 - 17:50 Panel discussion / Round Table.
Moderator: Marc Horner, Ansys
Speakers:
Kyriakos Hatzaras CEng Programme Officer – EU Policies
Frank Rademakers, KU Leuven
Anna Niarakis, University of Toulouse III
Alison Marsden, Stanford University
Liesbet Geris, VPHi
Thierry Marchal, Ansys

17:50 - 18:00 Wrap up

Thierry Marchal, Secretary General, Avicenna Alliance, Ansys

October 12th – Focus on Patients / Clinicians – «Involving and serving the Patients»

14:00 - 14:05 Welcome
Roberta Maggi, Office Manager, Avicenna Alliance

14:05 - 14:25 Introduction to the topic
Cyrille Thinnes, Public & Patient Involvement TFL, Master of Ceremony, Avicenna Alliance, NUI Galway

14:25 - 14:45 "Clinical use of 3D modeling and simulation for preoperative planning in congenital heart surgery",
Keynote 3 David Hoganson, Assistant in Cardiac Surgery, Department of Cardiac Surgery, Boston Children’s Hospital

14:45 - 15:05 "Person Centered Health Care”, Keynote Speaker, Daniel de Schryver, Patient Engagement & Advocacy Lead, Janssen

15:05 - 15:25 "It's not just a headache", Keynote Speaker, Pascal Derrien, CEO, Migraine Ireland

15:25 - 15:40 BREAK

15:40 - 15:55 “Patient Involvement: Myth or indisputable necessity?”, Anne Thorez, Senior Director Patient Engagement, VCLS

15:55 - 16:10 “Use of VR technologies to enhance the clinical uptake of the digital twin”, Claudio Capelli, Research Associate, University College London

16:10 - 16:25 "Responsible Research and Innovationinin silico Medicine: Bridging the gap between science and public", Zita Van Horenbeeck, Social Scientist, VPHi

16:25 - 16:35 "My experience of being an Embedded Patient Researcher", Case study, Robert Joyce, MS Patient Advocate, Embedded Patient Researcher, National University of Ireland, Galway

16:35 - 16:45 "Case studies of PPI involvement in Cancer Research", Case study 2 Frances Drummond, Research Manager, Breakthrough Cancer Research

16:45 - 16:55 "PPI workshop at a scientific congress - the way forward?", Case study, Marlène Mengoni, Associate Professor, University of Leeds

16:55 - 17:05 "EUPATI – enhancing patient involvement in research through education", Case study, Maria Dutarte, Executive Director, EUPATI

17:05 - 17:20 BREAK

17:20 - 18:00 Panel discussion / Round Table
Moderator: Cyrille Thinnes, NUI Galway
Speakers:
Avril Kennan, CEO, Health Research Charities Ireland
Steve Levine, Chair of PPI Task Force, Sr. Director of Virtual Human Modeling, Dassault Systèmes
Veronica Popa, Digital Patient Engagement Manager, EURORDIS

18:00 - 18:15 Wrap up
Thierry Marchal, Secretary General, Avicenna Alliance, Ansys

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