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What is In Silico medicine?

Predictive medicine or “in silico medicine” as a broader term, is the use of computer modelling and simulation in the diagnosis, treatment, prevention of a disease and development of products.

In silico medicine has only been made possible in the few decades with the vast roll out of high-throughput computing on an unprecedented scale. Processing huge quantities of complex data that can factor in all manner of variables and translating this into highly valuable knowledge is something that would have been unthinkable just a decade ago.

In silico has the potential to:

  • Allow phase one clinical trials to be done on computer rather than on animals, greatly reducing the costs for researchers and helping to achieve a reduction in animal testing as has been frequently called for by the European and national Parliaments;
  • Enable modelling of implants tailored to the individual so that scandals such as the metal on metal hip implant incident can be avoided completely and patients receive implants fitted to suit them, improving patient safety;
  • Provide training for young healthcare professionals so that surgeons can perform surgeries “in silico” making mistakes over and over virtually to avoid real mistakes on real patients;
  • Reduce the unnecessary use of drugs by processing individual patient data so that the patient receives the right treatment for them, reducing costly hospital stays and expediting their recovery.

Reducing research costs

Through better identification of promising new compounds and better predictability of which compounds are likely to fail, in silico can significantly reduce the failure rate of medicinal products and optimize the clinical trial process.

For many device designers their working methods have long involved the use of computer-aided techniques and, increasingly, anatomically-informed individualisation has contributed to the understanding and refinement of the product development process. Now in silico clinical trials offer the possibility of shortening and cost-reducing the time-to-market, by extending the computational involvement through to the regulatory phase of the process.

Improving patient safety

In silico medicine allows us to test scenarios which would be impossible or unethical to test in real patients. Testing the long term durability of metal on metal hip implants for example can allow us to develop safer and more effective medical devices that conform to the specifics of each patient. Similarly, with medicinal products, building advanced models based on the stratification of patients can help identify which patients may not be suited for particular treatments and allow greater predictability of drug efficacy.

Helping to avoid adverse reactions

There is always a leap of faith in transitioning from animal testing to testing in humans. In silico medicine can help make that leap significantly smaller. In silico applied to clinical development can change the paradigm entirely, switching from a costly trail/error model where phase 3 RCTs are exploratory to one where these Phase 3 become confirmaory of ex-ante in silico simulations, reinforcing the determination of new product value and focusing spending on the most promising scenarios.

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enhanced knowledge, improved decisions, better outcomes

Modelling and simulation

Modelling and simulation, which is the core of predictive medicine, is already used to improve decision making in a range of other industries such as aviation, finance and weather forecasting.

In aviation design

In aviation design, the use of modelling and simulation can reduce the need to design and build multiple prototypes.

relevant data Engineers take all the relevant data and build a computer model to help them decide which aircraft would be the fastest, safest and most efficient.

reduces the cost

This improves their decision making and reduces the cost of their research.

testing medical devices

The same principle can be applied to clinical trials, testing medical devices and early detection of diseases

NEWS

News Welcome ADSILICO to the Avicenna Alliance!

Welcome ADSILICO to the Avicenna Alliance!

We are delighted to announce that ADSILICO has officially joined the Avicenna Alliance! This partnership marks a significant milestone in our collective mission to advance in silico medicine and foster innovation in healthcare.

News Welcome Bioreme

Welcome Bioreme

We are thrilled to welcome BIOREME (Integrating data-driven BIOphysical models into REspiratory MEdicine), a pioneering collaborative network based in the UK, as Avicenna new Partner!

News Virtual launch of

Virtual launch of "Toward Good Simulation Practice" book

On May 8, 2024, the virtual launch of "Toward Good Simulation Practice: Best Practices for the Use of Computational Modeling and Simulation (CM&S) in the Regulatory Process of Biomedical Products" took place, marking a significant milestone in regulatory science and industry.

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