Colonoscopy
The diagnosis and severity grading of intestinal conditions such as Crohn’s disease typically require a complete colonoscopy with biopsy and relative histopathology exam. The VIGOR++ system makes possible to replace these invasive, unpleasant, and expensive exams with a simple magnetic resonance imaging session, followed by a patient-specific computer simulation.
The VIGOR++ software is now available for clinical research use via the 3Dnet™ medical imaging cloud service (www.3dnetmedical.com). Full-scale clinical trials are being designed at the Academic Medical Center, Amsterdam, and the UCL Hospital, London.
Tielbeek JA, Löwenberg M, Bipat S, Horsthuis K, Ponsioen CY, D'Haens GR, Stoker J. Serial magnetic resonance imaging for monitoring medical therapy effects in Crohn's disease. Inflamm Bowel Dis. 2013 Aug;19(9):1943-50. 10.1097/MIB.0b013e3182905536
Tielbeek, JA; Makanyanga, JC; Bipat, S; Pendsé, DA; Nio, CY; Vos, FM; Taylor, SA; Stoker, J; - (2013) Grading Crohn Disease Activity With MRI: Interobserver Variability of MRI Features, MRI Scoring of Severity, and Correlation With Crohn Disease Endoscopic Index of Severity. AJR Am J Roentgenol, 201 (6) 1220 - 1228. DOI:10.2214/AJR.12.10341
Mahapatra D, Schueffler P, Tielbeek J, Makanyanga J, Stoker J, Taylor S, VosF, Buhmann J., Automatic Detection and Segmentation of Crohn's Disease Tissues from Abdominal MRI, IEEE Trans Med Imaging. 2013.
Public dissemination: Euronews documentary http://www.euronews.com/2013/07/01/crohn-s-disease-the-inside-story
