02 - "In silico tools for skeletal tissue engineering from bench to bedside"
Topic of the webinar:
In silico tools for skeletal tissue engineering from bench to bedside
Panelist:
Liesbet Geris is a Professor at the University of Liège and at the Univeristy of KU Leuven. At the University of Liège, she is working in the Biomechanics Research Unit, GIGA In Silico Medicine. She is also working at the University of KU Leuven in the division Skeletal Tissue Engineering (Prometheus) as well as in the Biomechanics Section.
Abstract:
As basic science advances, one of the major challenges in Tissue Engineering (TE) is the translation of the increasing biological knowledge on complex cell and tissue behavior into predictive and robust engineering processes that allow for automation and upscaling. Mastering this complexity is an essential step towards clinical translation of TE applications. Computational (in silico) modeling allows to study the biological complexity and its translation in a more integrative and quantitative way.
Within the Biomechanics Research Unit, we have developed computational models related to all aspects of the TE product development cycle. These models range from models of intracellular regulation, over scaffold and bioreactor design to models of bone regeneration in vivo. The in silico techniques used depend on the context of use and encompass the whole spectrum from phenomenological to mechanistic. Our group is embedded in Prometheus, the skeletal TE transdisciplinary platform of the KU Leuven and the University of Liège where both classical and developmentally-inspired tissue engineering approaches are investigated for skeletal applications. To bring these models to the clinics and/or the market, various collaborations have been set up with clinicians and companies, in Belgium and Europe.
In this talk Liesbet Geris will discuss our in vitro, in vivo and in silico models used in the development of living implants for bone and cartilage.
