33 - "In silico trial simulation platform Jinkō"
Dr. Shiny Martis B
Academic Partnership and Customer Success Scientist at Nova Discovery
PhD Biomathematics, Bioinformatics and Evolutionary Genomics from Lyon University, France and M.Tech Bioinformatics from VTU, Belgium
Dr. Claudio Monteiro
Executive Manager | Modeling & Simulation at Nova Discovery
Ph.D Biomathematics, Biostatistics and Bioinformatics and MSc Pharmacology, Modeling and Clinical Trials from Lyon University, France
These past few years have marked the acceleration of the adoption of in silico for more efficient and innovative clinical research. When embarking on a new R&D program, scientists face a strategic imperative to assemble the best and most relevant available data and insights. Jinkō has been designed to build and maintain a high-quality knowledge repository, allowing teams to seamlessly cooperate, both internally and with external thought leaders.
During the first part of this webinar Dr Shiny Martis B will explain how jinkō can be used to extract, classify and qualify pieces of knowledge in a systematic, transparent and traceable manner, and use these in research reports and literature reviews. After that Dr Claudio Monteiro will showcase how this knowledge is then leveraged directly within jinkō to help lower the cost and ethical constraints as well as achieve greater trial efficiency through the design and simulation of in silico trials. This will be illustrated with two practical use cases using nova's non small cell lung cancer (NSCLC) disease model of epidermal growth factor receptor (EGFR) mutated lung adenocarcinoma (LUAD). First, by exploring a large range of doses and then by testing eligibility criteria refinement and its impact on treatment effectiveness.