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43 - "Digital Modelling at the University of Sydney: Pharmaceutical Inhaler Studies, Digestion Processes and Pedeatric Heart Valve Development"

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43 - "Digital Modelling at the University of Sydney: Pharmaceutical Inhaler Studies, Digestion Processes and Pedeatric Heart Valve Development"

Abstract

The advancements in simulation driven by key industries, such as automotive, aeronautical, defence and nuclear, have revolutionised the capabilities of both simulation software and computer hardware over the last few decades. The spin-off is that these methods and technologies can now be applied to biological and biomedical processes, enabling greater understanding of how the body and medical devices function. Whilst this alone is an important step, the potential of simulation has not been fully realised in shortening regulatory approvals and saving time and cost to market. We will illustrate how simulation can have a huge impact, especially when it is performed with verification and validation as the backbone of the work. The diversity of the cases presented highlights the huge potential of simulation and the need to train and hire simulation specialists.

Biographies

David Fletcher has a BSc and PhD in mathematics from the University of Exeter UK, and an Habilitation à Diriger des Recherches in Chemical Engineering from the Institut National Polytechnique de Toulouse, France. He runs his own consultancy providing specialist CFD advice, model development and training services, which includes being a CFD Specialist for LEAP Australia, distributors of the Ansys software in Australia and New Zealand, and an Adjunct Professor at The University of Sydney. His expertise is in the numerical simulation of fluid flow, heat and mass transfer and coupled systems, including Fluid Structure Interaction (FSI) problems. In his 40-year career, he has published over 300 journal papers on CFD, with an emphasis on combustion, multiphase flow, mixing, micro-flows, pharmaceutical inhaler design and a wide range of biomedical applications, including heart valve modelling.

Dr. Xinying Liu is a Research Associate at the School of Chemical and Biomolecular Engineering, University of Sydney, specializing in Computational Fluid Dynamics (CFD), Fluid-Structure Interaction (FSI), and multiphysics simulation for biomedical engineering problems. Her research focuses on revolutionizing healthcare technologies and improving patient outcomes by developing advanced modelling and simulation techniques for complex fluid systems. With expertise in cardiovascular hydrodynamics and gastric flow systems, she contributes to a deeper understanding of physiological processes and the development of innovative medical treatments.

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