61 - “In silico medicine and digital twins through the foundational paradigm of in silico oncology: historical landmarks and current evolutionary status”
Abstract:
A brief, yet comprehensive, overview of the formal emergence of in silico medicine through its foundational paradigm of in silico radiation oncology in 2002 will be presented. To this end, in addition to pertinent peer reviewed scientific articles and other official publications, Google®’s generative AI platform "GEMINI® - Deep Research" has been recruited and its generated report has been independently validated. The Clinical Oncosimulator, proved to be the first digital (virtual) twin in oncology and beyond - presented in 2007 - will also be delineated. Key evolutionary landmarks of in silico oncology and in silico medicine will be listed. Oncosimulators for glioblastoma multiforme, paediatric nephroblastoma, lung cancer, breast cancer, cervix cancer, prostate cancer and acute lymphoblastic leukemia, along with their clinical validation and translational statuses will be outlined. The current evolutionary status ofin silico oncology, including cancer digital (virtual) twins, in conjunction with expected future accomplishments, will be sketched.
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