07 - "Preclinical assessment of the effect of skeletal interventions with physiology based computational modelling"
Topic: Preclinical assessment of the effect of skeletal interventions with physiology based computational modelling
Panelist: Dr Enrico Dall'Ara, Department of Oncology and Metabolism and Insigneo Institute for in silico medicine, University of Sheffield, UK
Abstract:
Currently the journey of a new pharmacological product from discovery to the market is very long and expensive, due to the high failure rate. Musculoskeletal diseases affect dramatically the quality of life of patients in our ageing society, with impact similar to those of cancer and cardiovascular diseases.
In this webinar in silico approaches to assess the effects of diseases and treatments preclinically in mouse models will be introduced. The usage of longitudinal high-resolution imaging for estimating the effect of induced accelerated bone resorption and combined bone anabolic interventions on the morphometric, densitometric and biomechanical properties of the bone will be described. Finally advantages and current limitations of computational models of bone remodelling will be presented.
