13 - “Heterogeneous modelling to explore the degeneration of load-bearing tissues and organs”
ABSTRACT: The management of highly multifactorial conditions of load-bearing organs and tissues remains poorly efficient, despite all the important advances. Over the last decades, numerical models in biomechanics have allowed to improve our understanding of several conditions, yet, the translation of mechanical predictions into biology-based rationales remains a major challenge, to target promising biomarkers for prevention, early diagnosis and treatment. Theoretical tissue constitutive models in continuum mechanics can explicitly integrate tissue composition parameters through multiphysics and/or multiscale modelling and pave the way to mechanistic descriptions of couplings through which organ and tissue biomechanics are affected by composition changes, the latter being regulated by the dynamic behaviour of cells in multifactorial micro-environments. Modelling technologies can be combined to generate simulation workflows able to rationally interpolate real world data and provide interpretation support systems for improved diagnosis and prevention. Applications cases include arthropathies, lung emphysema, osteoporosis and atherosclerosis.
OUR SPEAKER:
Jérôme Noailly, Universitat Pompeu Fabra (UPF)
PhD from the Universitat Politècnica de Catalunya (UPC), Barcelona, Spain,
2009: best PhD thesis award in engineering.
2016: Ramon y Cajal Fellowship Award by the Spanish Government
2019: Tenure Track Associate Professor at UPF.
Jérôme was the principal investigator of the FP7 EU project MySpine and he is the current coordinator of the H2020 EU project Disc4All. Regularly in charge of clinical and technological transfer activities in computational biomechanics with companies and hospitals, he chairs the Student Committee and the AI Task Force of the VPHi and Avicenna Alliance, and he is member of the Council of the European Society of Biomechanics.
